Former Felsted schoolboy Max Malins has been officially ruled out of England's first autumn international against Tonga through injury.
The Pacific islanders visit Twickenham on Saturday but the Premiership's leading try-scorer will not feature.
Head coach Eddie Jones said: "We had Max Malins and Raffi Quirke come into camp with injuries.
"They've been rehabbing but won't be considered for selection for the Tongan game, but we're hopeful they'll be fitter further down the track."
To make matters worse Malins' replacement, Louis Lynagh, has also been ruled out after a bruising encounter for Harlequins against Saracens on Sunday.
"Louis came in a bit beaten up after the game and so he hasn't been able to train with us," Jones said.
"With Max unavailable because of the injury he brought into camp, we just thought we needed additional cover. But unfortunately Louis is injured as well.
Lynagh's club-mate at the Stoop, Marcus Smith is also a doubt for Saturday's game.
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here